Harald Renz Selected Research

Catalytic DNA (Deoxyribozyme)

1/2018	A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial.
1/2017	GATA-3-specific DNAzyme - A novel approach for stratified asthma therapy.
1/2017	Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.
1/2017	Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients.
2/2016	Efficacy of T-cell transcription factor-specific DNAzymes in murine skin inflammation models.
9/2015	Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma.
10/2013	Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs.
7/2012	Development of drug delivery systems for the dermal application of therapeutic DNAzymes.
4/2012	Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymes.
4/2008	Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme.

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Harald Renz Research Topics

Disease

78	Asthma (Bronchial Asthma) 01/2022 - 06/2002
43	Inflammation (Inflammations) 01/2022 - 09/2002
39	Hypersensitivity (Allergy) 01/2022 - 03/2002
11	Infections 01/2022 - 02/2003
10	Respiratory Hypersensitivity 05/2015 - 02/2003
9	COVID-19 01/2022 - 01/2020
9	Atopic Dermatitis (Atopic Eczema) 01/2021 - 02/2003
8	Food Hypersensitivity (Food Allergy) 12/2021 - 01/2005
7	Eosinophilia 01/2022 - 05/2003
6	Neoplasms (Cancer) 01/2021 - 01/2012
5	Pneumonia (Pneumonitis) 01/2022 - 05/2005
5	Allergic Rhinitis 01/2022 - 05/2005
4	Human Influenza (Influenza) 01/2022 - 01/2018
3	Connective Tissue Diseases (Connective Tissue Disease) 01/2022 - 01/2021
3	Virus Diseases (Viral Diseases) 01/2021 - 06/2007
3	Colitis 01/2018 - 01/2017
3	Airway Remodeling 01/2014 - 01/2007
3	Hyperplasia 01/2014 - 04/2005
2	Severe Acute Respiratory Syndrome 01/2022 - 01/2021
2	Anaphylaxis (Anaphylactic Shock) 01/2022 - 01/2020
2	Necrosis 01/2022 - 01/2017
2	Eczema 12/2021 - 04/2008
2	Myositis (Idiopathic Inflammatory Myopathies) 01/2021 - 01/2021
2	Systemic Scleroderma (Systemic Sclerosis) 01/2021 - 01/2021
2	Fibrosis (Cirrhosis) 01/2021 - 11/2011
2	Obesity 01/2021 - 01/2015
2	Disease Progression 01/2020 - 12/2019
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2018 - 07/2014
2	Respiratory Sounds (Crackle) 01/2018 - 10/2015
2	Noncommunicable Diseases 01/2016 - 01/2015
2	Immediate Hypersensitivity 03/2010 - 10/2009
2	Autoimmune Diseases (Autoimmune Disease) 06/2007 - 02/2003
2	Communicable Diseases (Infectious Diseases) 10/2006 - 03/2002
2	Airway Obstruction (Choking) 02/2004 - 05/2003
2	Lung Diseases (Lung Disease) 12/2003 - 06/2002
2	Metaplasia 06/2003 - 05/2003
1	Critical Illness (Critically Ill) 01/2022
1	Pain (Aches) 01/2022
1	Edema (Dropsy) 01/2022
1	Osteonecrosis (Kienbock's Disease) 01/2022

Drug/Important Bio-Agent (IBA)

47	AllergensIBA 01/2022 - 09/2002
19	CytokinesIBA 01/2022 - 06/2003
19	Immunoglobulin E (IgE)IBA 01/2022 - 09/2002
14	AntibodiesIBA 01/2022 - 09/2002
13	Nerve Growth Factors (Neurotrophins)IBA 01/2012 - 02/2003
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2013
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2004
10	Catalytic DNA (Deoxyribozyme)IBA 01/2018 - 04/2008
10	Nerve Growth Factor (NGF)IBA 01/2012 - 09/2002
8	OvalbuminIBA 01/2018 - 09/2002
7	Immunoglobulin G (IgG)IBA 01/2022 - 05/2003
7	AntigensIBA 01/2020 - 03/2002
7	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2006 - 05/2003
6	AutoantibodiesIBA 01/2022 - 10/2004
6	AutoantigensIBA 01/2022 - 10/2004
6	Interleukin-5 (Interleukin 5)IBA 01/2020 - 06/2003
6	AcidsIBA 01/2017 - 01/2007
5	Histones (Histone)IBA 10/2020 - 07/2015
5	Interleukin-13IBA 01/2020 - 06/2003
5	Interleukin-6 (Interleukin 6)IBA 01/2019 - 02/2005
5	Methacholine Chloride (Methacholine)FDA Link 05/2015 - 06/2003
4	VaccinesIBA 01/2021 - 01/2016
4	Peptides (Polypeptides)IBA 01/2020 - 08/2005
4	Messenger RNA (mRNA)IBA 01/2017 - 08/2006
4	Transcription Factors (Transcription Factor)IBA 02/2016 - 01/2006
4	AerosolsIBA 10/2009 - 09/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022 - 05/2015
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2014
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 01/2007
3	Therapeutic UsesIBA 07/2017 - 06/2003
3	Interleukin-4 (Interleukin 4)IBA 01/2017 - 06/2003
3	CollagenIBA 01/2014 - 04/2005
2	beta-cyclodextrin tetradecasulfate (CTDS)IBA 01/2022 - 01/2021
2	Pharmaceutical PreparationsIBA 12/2021 - 07/2012
2	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2013
2	EnzymesIBA 01/2021 - 11/2020
2	Butyrates (Butyrate)IBA 11/2020 - 01/2017
2	HomocysteineIBA 01/2020 - 04/2010
2	Hormones (Hormone)IBA 01/2018 - 09/2016
2	Phosphates (Orthophosphate)IBA 01/2018 - 03/2014
2	Interleukin-2 (IL2)IBA 01/2018 - 01/2006
2	Cystatin CIBA 12/2017 - 09/2016
2	CreatinineIBA 12/2017 - 09/2016
2	InterleukinsIBA 01/2017 - 10/2011
2	RNA (Ribonucleic Acid)IBA 01/2017 - 10/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2014 - 10/2011
2	Conjugated Linoleic AcidsIBA 01/2014 - 12/2010
2	Interleukin-10 (Interleukin 10)IBA 10/2011 - 06/2007
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2010 - 11/2007
2	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2009 - 04/2008
2	Immunoglobulin A (IgA)IBA 10/2009 - 02/2003
2	Arginine (L-Arginine)FDA Link 09/2009 - 05/2009
2	Toll-Like Receptor 2IBA 04/2008 - 03/2004
2	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 01/2004 - 02/2003
1	OzoneIBA 01/2022

Therapy/Procedure

23	Therapeutics 01/2022 - 01/2007
6	Immunotherapy 12/2019 - 03/2002
2	Biological Therapy 01/2021 - 07/2017
1	Wearable Electronic Devices 01/2022
1	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2022